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cenobamate will reduce the extent or outcome of fentanyl transdermal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Closely. Maximize dose of CYP3A4 substrate, as required, when coadministered with cenobamate.butorphanol decreases results of fentanyl transdermal by pharmacodynamic antagonism. Avoid or Use Alt